Polynucleotide treatment costs, including price trends, affordability, and key factors influencing expenses.
Unlike dermal fillers, which add volume, PN treatments work by stimulating the body’s natural production of collagen and elastin.
What Are Polynucleotide Treatments?
Polynucleotide treatment often referred to as salmon sperm facials involve the use of purified DNA and RNA fragments derived from salmon or trout. First introduced in South Korea around 2015, these treatments have since become popular across Europe and other regions.
They are administered using fine needles or a cannula and are commonly applied to delicate areas such as the eyes, face, neck, hands, and scalp for hair revitalization.
Typically performed over 2–4 sessions spaced 2–4 weeks apart, the effects develop gradually over weeks to months and can last between 6 and 12 months.
The Unique Science Behind Polynucleotides
Polynucleotide treatment cost work through multiple mechanisms: they attract and retain moisture, neutralize damaging free radicals, and strongly activate fibroblasts—the cells responsible for producing collagen and elastin.
This comprehensive approach supports deep hydration, scar healing, reduction of fine lines, calming of pigmentation, and overall structural skin rejuvenation. Unlike fillers, which primarily add volume, PN treatments encourage the skin to repair and regenerate itself, promoting gradual, natural-looking improvements over time.
Global Popularity and Regulatory Status in 2025
By early 2025, polynucleotide (PN) treatments had become widely established in South Korea and Europe, with growing attention from celebrities like Jennifer Aniston and Charli XCX helping drive their popularity.
While commonly offered in clinics across the UK and EU, PN injectables are not yet FDA-approved in the U.S., where they’re only available off-label or in topical form.
How Much Do Polynucleotide Sessions Cost in 2025?
Pricing for PN treatments varies significantly depending on the clinic, treatment area, and product brand. In the UK, average costs per single session typically range from £199 to £400, with high-end clinics charging up to £900 per session. In London, approximate rates are:
- Eyes only: £199–£395
- Full face or neck: £275–£900
- Multi-area (face + neck + eyes): Around £900
Prices reflect the clinic’s reputation, practitioner expertise, the brand of polynucleotide used, and the treatment’s complexity or coverage.
Package Deals vs. À la Carte Sessions
Many clinics offer discounted packages for multiple sessions, which not only reduce per-session cost but also support better results. Examples of UK package pricing:
- Eyes (3 sessions): £183–£300 per session
- Face (2 sessions): £247.50/session)
- Face (3 sessions): £700–£995 (~£233–£332 per session)
Packages encourage patient commitment and are more cost-effective than standalone treatments.
Are Prices Higher in Premium London Clinics?
Yes. Elite clinics in areas like Marylebone, Harley Street, and Knightsbridge charge significantly more, reflecting their expertise, personalized service, and use of premium international brands. Approximate rates include:
- Eyes: £350–£395 per session
- Full face: £900+ per session
- Premium 3-session packages: £950–£2,800, depending on treated areas and volume used
Understanding Cost Drivers
What Determines the Price of Polynucleotide Treatments?
Several key factors influence the cost of PN treatments:
Treatment Area: Smaller areas like the eyes are less expensive (typically £199–£400), while larger zones such as the full face or neck require more product and are priced higher.
Number of Vials Used: Cost scales with quantity:
Eyes (2–3 vials): £850–£1,200
Full face (6–8 vials): £2,250–£2,800
Clinic Reputation: High-end clinics often charge more due to their location, ambiance, advanced technology, and experienced practitioners.
Brand of Polynucleotide: Products like Plinest, Nucleofill, and PhilArt vary in formulation, concentration, and cost, influencing session prices.
UK Pricing Snapshot: Clinic-by-Clinic Comparison
Here’s a look at how prices vary across different UK clinics:
| Clinic | Treatment | Price |
| Skinoza Clinic | Eyes | £230 (1 session) |
| Face/Neck | £300 | |
| 3-session Face | £700 | |
| 3-session Neck | £700 | |
| Premier Laser & Skin | Full Face | £275 (2 sessions for £495) |
| Eyes | £199 (2 for £350) | |
| HAVA Aesthetics (Harley St.) | Single Session | £350 |
| 3 Sessions | £950 | |
| Cosmedics | PhilArt (Single) | £395 |
| Consultation | £75 | |
| Dr SNA Clinic | Eyes | £850–£1,200 |
| Full Face | £2,250–£2,800 |
How Long Do Results Last—and What Affects Them?
Polynucleotide treatment results generally last 6–9 months, with some patients experiencing benefits up to 12 months. Longevity depends on:
- Skin quality and age
- Consistency with treatment protocols
- Lifestyle factors (e.g., sun exposure, smoking, skincare habits)
Maintenance sessions, which many clinics recommend every 6–12 months for optimal results
Cost Comparison: Polynucleotides vs. Fillers & Botox
PN sessions (typically £200–£900) are comparable to:
- Mid-range dermal fillers: £160–£280 per ml
- Botox: £140–£180 per area
While fillers like chin filler and Botox provide immediate, surface-level improvements, polynucleotides stimulate deep skin regeneration and collagen production. This cellular-level repair can reduce the need for frequent touch-ups, offering better value over time.
Additional Costs & Aftercare Considerations
When budgeting for PN treatments, patients should also consider:
- Consultations: £0–£100 (sometimes redeemable against treatment)
- Top-ups: Smaller doses (e.g., £425 at Dr SNA) may be needed between courses
- Aftercare products: Soothing creams, SPF, arnica for bruising
- Downtime: Minor redness or bruising may last up to 2 days
Adjunct treatments: Some patients pair PNs with microneedling, fillers, or energy-based procedures for enhanced results
Is It Worth It? Benefits vs. Costs
PN treatments offer natural rejuvenation, targeting cellular repair, hydration, elasticity, scar reduction, and pigmentation—a holistic benefit unmatched by fillers or Botox. Many users report healthier, glowing skin and fewer maintenance visits. Yet, pain tolerance, slower results, and potential variability—some feel little change —must be weighed against cost and discomfort.
Risks, Discomfort & Patient Experience
Side effects are usually mild: redness, swelling, bruising, and discomfort for 1–2 days. Allergic reactions are rare due to the purity level. Pain levels vary—needle injection, especially around cheeks or eyes, can cause considerable discomfort. The use of a cannula and numbing cream can moderate pain.
How to Choose a Clinic in 2025
Look for clinics staffed by licensed medical professionals—dermatologists, plastic surgeons, or trained aesthetic practitioners—who have formal training and substantial experience administering polynucleotide injections. Experienced practitioners understand proper injection techniques, dosage, and patient-specific considerations, reducing risks and improving outcomes.
Verify the Products Used
Ask which brands or types of polynucleotides the clinic uses. Leading brands like Plinest, PhilArt, and Nucleofill have different concentrations, purity levels, and clinical studies supporting their efficacy. Clinics using well-known, medically approved products tend to offer better and safer results than those sourcing from unverified suppliers.
Review Clinic Hygiene and Safety Protocols
A reputable clinic should follow strict hygiene standards, including the use of sterile equipment, disposable needles, and appropriate sanitization procedures. Confirm that the facility is registered with relevant health authorities and complies with local regulations to minimize infection risks.
Consider Clinic Reputation and Reviews
Look for clinics with positive patient testimonials, before-and-after galleries, and a transparent track record of results. Online reviews on platforms like Google, RealSelf, or clinic websites can provide insights into patient satisfaction, treatment efficacy, and practitioner professionalism.
Evaluate Pricing Transparency
Beware of clinics offering prices that seem unusually low, which could indicate substandard products or inexperienced practitioners. The best clinics provide clear, upfront pricing, including consultation fees, treatment costs, and any follow-up sessions or aftercare products.
Future Trends and Cost Outlook for PN
Market Growth and Adoption
The global market for polynucleotide injectables is experiencing significant growth. In Europe, the market is projected to reach USD 82.6 million by 2030, growing at a compound annual growth rate (CAGR) of 15.2% from 2025 to 2030.
Similarly, the UK market is expected to grow from USD 6.8 million in 2024 to USD 15.9 million by 2030, with a CAGR of 15%. This growth is driven by increasing consumer demand for advanced skin rejuvenation treatments and the rising popularity of non-invasive procedures.
Cost Trends and Accessibility
The cost of polynucleotide treatments varies based on factors such as treatment area, clinic location, and the number of sessions required. For instance, in the UK, the price for a single session can range from £150 to £900, depending on the area treated and the clinic’s pricing structure.
While these treatments are generally more affordable than surgical alternatives, the cumulative cost can be significant, especially for multi-session protocols.
To make these treatments more accessible, some clinics offer package deals that provide a discount for multiple sessions. Additionally, as the market grows and competition increases, there is potential for prices to stabilize or decrease over time, making polynucleotide treatments more accessible to a broader audience.
Technological Advancements and Combination Therapies
Advancements in biotechnology are contributing to the evolution of polynucleotide treatments. Clinics are increasingly combining polynucleotides with other regenerative agents, such as hyaluronic acid and growth factors, to enhance the efficacy of treatments.
These combination therapies aim to improve skin elasticity, accelerate wound healing, and provide more comprehensive rejuvenation.
Regional Variations and Cultural Influences
The adoption of polynucleotide treatments varies across regions, influenced by cultural preferences and regulatory environments. In South Korea, for example, there is a strong emphasis on innovative anti-aging solutions, leading to rapid adoption of polynucleotide-based products. In contrast, in regions where regulatory approval is pending or consumer awareness is lower, the adoption rate may be slower.
Conclusion
As we step into mid-2025, polynucleotide (PN) treatments have established themselves as one of the most promising advancements in aesthetic medicine. Offering more than superficial improvements, these treatments work on a cellular level.
Stimulating collagen, improving hydration, reducing pigmentation, and enhancing skin elasticity. For patients seeking natural-looking results without the volumizing effects of traditional fillers or the frozen look of excessive Botox, polynucleotides offer an appealing alternative.